Deoxyribonucleic acid (DNA) is a nucleic acid A nucleic acid is a macromolecule composed of chains of monomeric nucleotides. In biochemistry these molecules carry genetic information or form structures within cells. The most common nucleic acids are deoxyribonucleic acid and ribonucleic acid (RNA). Nucleic acids are universal in living things, as they are found in all cells and viruses that contains the genetic Genetics , a discipline of biology, is the science of heredity and variation in living organisms. The fact that living things inherit traits from their parents has been used since prehistoric times to improve crop plants and animals through selective breeding. However, the modern science of genetics, which seeks to understand the process of instructions used in the development and functioning of all known living organisms In biology, an organism is any living system . In at least some form, all organisms are capable of response to stimuli, reproduction, growth and development, and maintenance of homeostasis as a stable whole. An organism may either be unicellular (single-celled) or be composed of, as in humans, many billions of cells grouped into specialized and some viruses A virus is a small infectious agent that can only replicate inside the cells of another organism. Viruses are too small to be seen directly with a light microscope. Viruses infect all types of organisms, from animals and plants to bacteria and archaea. Since the initial discovery of tobacco mosaic virus by Martinus Beijerinck in 1898, about 5,000. The main role of DNA molecules A molecule is defined as an electrically neutral group of at least two atoms in a definite arrangement held together by very strong chemical bonds. Molecules are distinguished from polyatomic ions in this strict sense. In organic chemistry and biochemistry, the term molecule is used less strictly and also is applied to charged organic molecules is the long-term storage of information Information as a concept has many meanings, from everyday usage to technical settings. The concept of information is closely related to notions of constraint, communication, control, data, form, instruction, knowledge, meaning, mental stimulus, pattern, perception, and representation. DNA is often compared to a set of blueprints A blueprint is a type of paper-based reproduction usually of a technical drawing, documenting an architecture or an engineering design. More generally, the term "blueprint" has come to be used to refer to any detailed plan or a recipe, or a code In communications, a code is a rule for converting a piece of information into another form or representation (one sign into another sign), not necessarily of the same type. In communications and information processing, encoding is the process by which information from a source is converted into symbols to be communicated. Decoding is the reverse, since it contains the instructions needed to construct other components of cells The cell is the basic structural and functional unit of all known living organisms. It is the smallest unit of life that is classified as a living thing, and is often called the building block of life. Some organisms, such as most bacteria, are unicellular . Other organisms, such as humans, are multicellular. (Humans have an estimated 100 trillion, such as proteins Proteins are organic compounds made of amino acids arranged in a linear chain and folded into a globular form. The amino acids in a polymer chain are joined together by the peptide bonds between the carboxyl and amino groups of adjacent amino acid residues. The sequence of amino acids in a protein is defined by the sequence of a gene, which is and RNA Ribonucleic acid is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate. RNA is very similar to DNA, but differs in a few important structural details: in the cell, RNA is usually single-stranded, while DNA is usually double- molecules. The DNA segments that carry this genetic information are called genes A gene is the basic unit of heredity in a living organism. All living things depend on genes. Genes hold the information to build and maintain an organism's cells and pass genetic traits to offspring. A modern working definition of a gene is "a locatable region of genomic sequence, corresponding to a unit of inheritance, which is associated, but other DNA sequences have structural purposes, or are involved in regulating the use of this genetic information.

Chemically, DNA consists of two long polymers A polymer is a large molecule composed of repeating structural units typically connected by covalent chemical bonds. While polymer in popular usage suggests plastic, the term actually refers to a large class of natural and synthetic materials with a variety of properties of simple units called nucleotides Nucleotides are molecules that, when joined together, make up the structural units of RNA and DNA. In addition, nucleotides play central roles in metabolism. In that capacity, they serve as sources of chemical energy , participate in cellular signaling (cyclic guanosine monophosphate and cyclic adenosine monophosphate), and are incorporated into, with backbones In organic chemistry, the backbone chain of a polymer is the series of covalently bonded atoms that together create the continuous chain of the molecule made of sugars Sugar is a class of edible crystalline substances, mainly sucrose, lactose, and fructose. Human taste buds interpret its flavor as sweet. Sugar as a basic food carbohydrate primarily comes from sugar cane and from sugar beet, but also appears in fruit, honey, sorghum, sugar maple , and in many other sources. It forms the main ingredient in candy and phosphate A phosphate, an inorganic chemical, is a salt of phosphoric acid. In organic chemistry, a phosphate, or organophosphate, is an ester of phosphoric acid. Organic phosphates are important in biochemistry and biogeochemistry or ecology. Inorganic phosphates are mined to obtain phosphorus for use in agriculture and industry. At elevated temperatures groups joined by ester Esters are chemical compounds derived by reacting an oxoacid with a hydroxyl compound such as an alcohol or phenol. Esters are usually derived from an inorganic acid or organic acid in which at least one -OH (hydroxyl) group is replaced by an -O-alkyl (alkoxy) group, and most commonly from carboxylic acids and alcohols bonds. These two strands run in opposite directions to each other and are therefore anti-parallel In DNA, the 5' carbon is located at the top of the leading strand, and the 3' carbon is located at the lower section of the lagging strand. The nucleotides are similar and parallel, but they go in opposite directions, hence the antiparallel designation. The antiparallel structure of DNA is important in DNA replication because it unzips the leading. Attached to each sugar is one of four types of molecules called bases Nucleobases are the parts of DNA and RNA that may be involved in pairing (see also base pairs). The main ones are cytosine, guanine, adenine (DNA and RNA), thymine (DNA) and uracil (RNA), abbreviated as C, G, A, T, and U, respectively. They are usually simply called bases in genetics. Because A, G, C, and T appear in the DNA, these molecules are. It is the sequence of these four bases along the backbone that encodes information. This information is read using the genetic code The genetic code is the set of rules by which information encoded in genetic material is translated into proteins (amino acid sequences) by living cells. A more precise term for the concept might be "genetic cipher". The code defines a mapping between tri-nucleotide sequences, called codons, and amino acids. A triplet codon in a nucleic, which specifies the sequence of the amino acids Amino acids are molecules containing an amine group, a carboxylic acid group and a side chain that varies between different amino acids. These molecules are particularly important in biochemistry, where this term refers to alpha-amino acids with the general formula H2NCHRCOOH, where R is an organic substituent. In the alpha amino acids, the amino within proteins. The code is read by copying stretches of DNA into the related nucleic acid RNA, in a process called transcription Transcription, or RNA synthesis, is the process of creating an equivalent RNA copy of a sequence of DNA. Both RNA and DNA are nucleic acids, which use base pairs of nucleotides as a complementary language that can be converted back and forth from DNA to RNA in the presence of the correct enzymes. During transcription, a DNA sequence is read by RNA.

Within cells, DNA is organized into long structures called chromosomes A chromosome is an organized structure of DNA and protein that is found in cells. It is a single piece of coiled DNA containing many genes, regulatory elements and other nucleotide sequences. Chromosomes also contain DNA-bound proteins, which serve to package the DNA and control its functions. The word chromosome comes from the Greek χρῶμα. These chromosomes are duplicated before cells divide Cell division is the process by which a parent cell divides into two or more daughter cells. Cell division is usually a small segment of a larger cell cycle. This type of cell division in eukaryotes is known as mitosis, and leaves the daughter cell capable of dividing again. The corresponding sort of cell division in prokaryotes is known as binary, in a process called DNA replication DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "semiconservative" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two. Eukaryotic organisms A eukaryote is an organism whose cells contain complex structures enclosed within membranes. The defining membrane-bound structure that sets eukaryotic cells apart from prokaryotic cells is the nucleus, or nuclear envelope, within which the genetic material is carried. The presence of a nucleus gives eukaryotes their name, which comes from the (animals Animals are a major group of mostly multicellular, eukaryotic organisms of the kingdom Animalia or Metazoa. Their body plan eventually becomes fixed as they develop, although some undergo a process of metamorphosis later on in their life. Most animals are motile, meaning they can move spontaneously and independently. All animals are also, plants Plants are living organisms belonging to the kingdom Plantae. They include familiar organisms such as trees, herbs, bushes, grasses, vines, ferns, mosses, and green algae. The scientific study of plants, known as botany, has identified about 350,000 extant species of plants, defined as seed plants, bryophytes, ferns and fern allies. As of 2004,, fungi A fungus is a member of a large group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. The Fungi (pronounced /ˈfʌndʒaɪ/ or /ˈfʌŋɡaɪ/) are classified as a kingdom that is separate from plants, animals and bacteria. One major difference is that fungal cells have cell, and protists Protists , are a diverse group of eukaryotic microorganisms. Historically, protists were treated as the kingdom Protista but this group is no longer recognized in modern taxonomy. Instead, it is "better regarded as a loose grouping of 30 or 40 disparate phyla with diverse combinations of trophic modes, mechanisms of motility, cell coverings) store most of their DNA inside the cell nucleus In cell biology, the nucleus , also sometimes referred to as the "control center", is a membrane-enclosed organelle found in eukaryotic cells. It contains most of the cell's genetic material, organized as multiple long linear DNA molecules in complex with a large variety of proteins, such as histones, to form chromosomes. The genes and some of their DNA in organelles In cell biology, an organelle is a specialized subunit within a cell that has a specific function, and is usually separately enclosed within its own lipid membrane, such as mitochondria In cell biology, a mitochondrion is a membrane-enclosed organelle found in most eukaryotic cells. These organelles range from 0.5–10 micrometers (μm) in diameter. Mitochondria are sometimes described as "cellular power plants" because they generate most of the cell's supply of adenosine triphosphate (ATP), used as a source of the or chloroplasts Chloroplasts are organelles found in plant cells and other eukaryotic organisms that conduct photosynthesis. Chloroplasts capture light energy to conserve free energy in the form of ATP and reduce NADP to NADPH through a complex set of processes called photosynthesis.[1] In contrast, prokaryotes The prokaryotes are a group of organisms that lack a cell nucleus (= karyon), or any other membrane-bound organelles. They differ from the eukaryotes, which have a cell nucleus. Most are unicellular, but a few prokaryotes such as myxobacteria have multicellular stages in their life cycles. The word prokaryote comes from the Greek πρό- (pro-) & (bacteria The bacteria ( [bækˈtɪərɪə] ; singular: bacterium)[α] are a large group of unicellular microorganisms. Typically a few micrometres in length, bacteria have a wide range of shapes, ranging from spheres to rods and spirals. Bacteria are ubiquitous in every habitat on Earth, growing in soil, acidic hot springs, radioactive waste, water, and and archaea The Archaea /ɑrˈkiːə/ are a group of single-celled microorganisms. A single individual or species from this domain is called an archaeon (sometimes spelled "archeon"). They have no cell nucleus or any other organelles within their cells. In the past they were viewed as an unusual group of bacteria and named archaebacteria but since) store their DNA only in the cytoplasm The cytoplasm is the part of a cell that is enclosed within the cell membrane. In eukaryotic cells, the contents of the cell nucleus are not part of the cytoplasm and are instead called the nucleoplasm. Also in eukaryotic cells, the cytoplasm contains organelles, such as mitochondria, which are filled with liquid that is kept separate from the. Within the chromosomes, chromatin Chromatin is the complex combination of DNA and protein that makes up chromosomes. It is found inside the nuclei of eukaryotic cells. It is divided between heterochromatin and euchromatin (extended) forms. The major components of chromatin are DNA (Genetic Formula) and histone proteins, although many other chromosomal proteins have prominent roles proteins such as histones In biology, histones are strongly alkaline proteins found in eukaryotic cell nuclei, which package and order the DNA into structural units called nucleosomes. They are the chief protein components of chromatin, act as spools around which DNA winds, and play a role in gene regulation. Without histones, the unwound DNA in chromosomes would be very compact and organize DNA. These compact structures guide the interactions between DNA and other proteins, helping control which parts of the DNA are transcribed.

This article is part of the series on:

Gene expression Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. These products are often proteins, but in non-protein coding genes such as rRNA genes or tRNA genes, the product is a functional RNA. The process of gene expression is used by all known life - eukaryotes , prokaryotes (bacteria a Molecular biology Molecular biology is the study of biology at a molecular level. The field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry. Molecular biology chiefly concerns itself with understanding the interactions between the various systems of a cell, including the interactions between DNA, RNA and protein topic (portal) (Glossary See also: gene expression, List of Glossaries, List of Natural Sciences Glossaries)

Introduction to Genetics Genetics studies how living organisms inherit features from their ancestors; for example, children often look like their parents. Genetics seeks to identify which features are inherited, and explain how these features are passed from generation to generation
General flow: DNA > RNA Messenger ribonucleic acid is a molecule of RNA encoding a chemical "blueprint" for a protein product. mRNA is transcribed from a DNA template, and carries coding information to the sites of protein synthesis: the ribosomes. Here, the nucleic acid polymer is translated into a polymer of amino acids: a protein. In mRNA as in DNA, genetic > Protein Proteins are organic compounds made of amino acids arranged in a linear chain and folded into a globular form. The amino acids in a polymer chain are joined together by the peptide bonds between the carboxyl and amino groups of adjacent amino acid residues. The sequence of amino acids in a protein is defined by the sequence of a gene, which is
special transfers The dogma is a framework for understanding the transfer of sequence information between sequential information-carrying biopolymers, in the most common or general case, in living organisms. There are 3 major classes of such biopolymers: DNA and RNA , and protein. There are 3×3 = 9 conceivable direct transfers of information that can occur between (RNA > RNA RNA-dependent RNA polymerase , or RNA replicase, is an enzyme that catalyzes the replication of RNA from an RNA template. This is in contrast to a typical RNA polymerase, which catalyzes the transcription of RNA from a DNA template, RNA > DNA In biochemistry, a reverse transcriptase, also known as RNA-dependent DNA polymerase, is a DNA polymerase enzyme that transcribes single-stranded RNA into single-stranded DNA. It also helps in the formation of a double helix DNA once the RNA has been reverse transcribed into a single strand cDNA. Normal transcription involves the synthesis of RNA, Protein > Protein)
Genetic code
Transcription
Transcription (Transcription factors, RNA Polymerase,promoter)

Prokaryotic / Archaeal / Eukaryotic

post-transcriptional modification (hnRNA,Splicing)
Translation
Translation (Ribosome,tRNA)

Prokaryotic / Archaeal / Eukaryotic

post-translational modification (functional groups, peptides, structural changes)
gene regulation
epigenetic regulation (Genomic imprinting)
transcriptional regulation
post-transcriptional regulation (sequestration, alternative splicing,miRNA)
translational regulation
post-translational regulation (reversible,irreversible)
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New Victim of 1970s Serial Killer Identified - FOXNews
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New Victim of 1970s Serial Killer Identified

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Forensic anthropologist Sharon Derrick said the victim was identified through DNA analysis as Joseph Allen Lyles, who was 17 when he disappeared in February ...

Teen may be victim of 1970s Houston serial killer The Associated Press



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In these pages I intend to give a basic understanding of the structure of DNA The parts that make it up and how they bond together I hope you find this useful and interesting The next four pages contain

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Fry your DNA : Don't go through scanners The Obambi.com Blog www ...
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Wednesday, November 4, 2009...5:12 am. Fry your . DNA. : Don't go through scanners. Jump to Comments Leave a Comment. Filed under Barack Obama. Leave a Reply. Click here to cancel reply. Name. E-mail (will not be published). Website ...

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How do regulatory sequences in DNA allow the specific expression of lest say a protein in the mammary glands?
Q. Lets say i was to create a transgenic animal, an animal which would secrete this protein in its milk. I would need to identify the promoter sequence that would allow the expression of this protein in the mammary glands. So, question is how would regulatory sequences work on the level of DNA to permit the specif expression? What technique could i use to isolate the regulatory sequence of the gene expresses specifically in the milk?
Asked by Philip - Sun Apr 19 15:28:16 2009 - - 1 Answers - 0 Comments

A. Use a protein expression experiment or a protein database to find a short list of proteins that are highly expressed in mammary tissues compared to other tissues. Use the DAVID database ( to query these proteins and find which promoter(s) expresses the genes for these proteins. If the species of animal you are working with does not have it's genome mapped you will have a hard time finding this information.
Answered by I come BLOOD - Tue Apr 21 14:35:51 2009

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