Tetrazolium Chloride Information
Triphenyl tetrazolium chloride, TTC, or simply Tetrazolium chloride is a redox indicator commonly used in biochemical experiments especially to indicate cellular respiration. It is a white crystalline powder, soluble in water, ethanol and acetone but insoluble in ether.
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TTC Assay
TTC (2,3,5-triphenyltetrazolium chloride) is a redox indicator used to differentiate between metabolically active and inactive tissues. The white compound is enzymatically reduced to red TPF (1,3,5-triphenylformazan) in living tissues due to the activity of various dehydrogenases (enzymes important in oxidation of organic compounds and thus cellular metabolism), while it remains as white TTC in areas of necrosis since these enzymes have been either denatured or degraded. Note: TTC is somewhat heat and light unstable so avoid these environments as much as possible.
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